Pediatric Dosing
Recommended starting dose and dose modifications for pediatric patients (2 to <18 years of age)1
VIJOICE is taken orally, once daily, with food, and at approximately the same time every day until disease progression or unacceptable toxicity occurs.
For pediatric patients ≥6 years of age: Consider a dose increase to 125 mg (one 125-mg tablet) for response optimization after 24 weeks of treatment with VIJOICE.
Dose reduction back to 50 mg may be required if ARs occur. Discontinue VIJOICE in patients who cannot tolerate the 50-mg dose.
For pediatric patients who turn 18 years of age: Consider a gradual dose increase up to 250 mg.
Recommended dose adjustment for ARs are available in the Prescribing Information or Patient Management Guide.
Additional information:
If a dose of VIJOICE is missed, it can be taken with food within 9 hours after the time it is usually taken. After more than 9 hours, skip the dose for that day. The next day, take VIJOICE at the usual time
If the patient vomits after taking the dose, advise the patient not to take an additional dose on that day and to resume the dosing schedule the next day at the usual time
If an AR occurs, there are dose reduction and interruption guidelines for VIJOICE. Some patients may need to stop taking the drug
Patients who are able to swallow tablets should swallow VIJOICE tablets whole. Tablets should not be chewed or split prior to swallowing. Click here if your patient is unable to swallow tablets.
qd, once daily; AR, adverse reaction.
Adult Dosing
Recommended starting dose and dose modifications for adult patients (≥18 years of age)1
VIJOICE is taken orally, once daily, with food, and at approximately the same time every day until disease progression or unacceptable toxicity occurs.
Dose reductions may be required if an AR occurs.
Discontinue VIJOICE in patients who cannot tolerate the 50-mg dose.
Recommended dose adjustment for ARs are available in the Prescribing Information or Patient Management Guide.
Additional information:
If a dose of VIJOICE is missed, it can be taken with food within 9 hours after the time it is usually taken. After more than 9 hours, skip the dose for that day. The next day, take VIJOICE at the usual time
If the patient vomits after taking the dose, advise the patient not to take an additional dose on that day and to resume the dosing schedule the next day at the usual time
If an AR occurs, there are dose reduction and interruption guidelines for VIJOICE. Some patients may need to stop taking the drug
Patients who are able to swallow tablets should swallow VIJOICE tablets whole. Tablets should not be chewed or split prior to swallowing. (Please read on to the next section for additional details.)
Patients Who Are Unable to Swallow Tablets
Patients who are unable to swallow tablets should take VIJOICE by following these steps1:
Place VIJOICE tablet or tablets in a glass containing 2 to 4 ounces of water, and let it stand for approximately 5 minutes. Make the suspension with water only.
Crush the tablet or tablets with a spoon, and stir until an oral suspension is obtained.
Administer the oral suspension immediately after preparation. Discard the oral suspension if it is not administered within 60 minutes after preparation.
After administration of the oral suspension, add approximately 2 to 3 tablespoons of water to the same glass. Stir with the same spoon to resuspend any remaining particles, and administer the entire contents of the glass. Repeat if particles remain.
Liquids other than water should not be used for making the oral suspension